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. 2018 Jan 25;8:1597. doi: 10.1038/s41598-018-19982-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation between OTUs and various clinical indices. The abundance of OTUs (top 50) enriched in saliva (a) and dental plaques (b) of ASD children and controls were analyzed for covariation with clinical variables using Spearman’s rank correlation. The correlation effect is indicated by a color gradient from blue (negative correlation) to red (positive correlation). Correlation coefficients and p-values (*p < 0.05) are shown. OTUs and clinical variables in the heat maps were ordered using unsupervised hierarchical clustering. BMI, Body Mass Index; DMFT, Decayed-Missing-Filled Teeth; DMFS, Decayed-Missing-Filled Surface; PLI, Plaque Index; GI, Gingival Index; BI, Bleeding Index; PD, Probing Depth; BOP, Bleeding on Probing; ABC score, scale of ASD severity.