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. 2018 Jan 25;8:1617. doi: 10.1038/s41598-018-20005-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Influence of VU041 to adult Drosophila behavior. (A) Percent of injected flies that displayed the ‘flightless’ phenotype after injection with solvent control, VU041, and VU937. Bars represent mean (n = 200) and error bars represent SEM. (B) Total distance traveled 60-minutes after injection of solvent control, VU041, or VU937. Bars represent mean (n = 30) and error bars represent SEM. Representative heat maps of fly movements during the 30-second recording period for control and vehicle control (C), VU937 (D), and VU041 treated flies (E). Asterisks represent statistical significance with *representing P < 0.05 and ***representing P < 0.0001 as determined by a one-way ANOVA with multiple comparisons test.