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. 2018 Jan 25;8:1617. doi: 10.1038/s41598-018-20005-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neurophysiological recordings from the CNS of third instar larvae of D. melanogaster after exposure to pharmacological modulators of GIRK and K_ATP channels. Representative nerve discharge traces before and after exposure to (A) ML297, (B) tolbutamide, and (C) pinacidil. Initial CNS spike discharge frequencies in spikes/second (Hz) for each experiment are given to the left of each trace. The nerves were ejected from the electrode at the end of the recording to ensure the spike discharge frequency was not noise that had developed throughout the recording procedure. (D) Concentration response curve for ML297, tolbutamide, and pinacidil against CNS nerve discharge of D. melanogaster larvae from replicated recordings (n = 3–5 concentration per curve, with each concentration replicated at least 5 times), as shown in C. Data points represent mean percentage increase of baseline spike discharge rate, and error bars represent SEM of drug concentrations replicated at least 5 times. When error bars are absent, it is because they are smaller than the size of the symbol. Asterisks represent statistical significance with *representing P < 0.05 as determined by an unpaired t-test to the average baseline spike discharge frequency.