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. 2018 Jan 25;8:1617. doi: 10.1038/s41598-018-20005-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of VU041 on the membrane potential of D. melanogaster larval muscle. (A) Representative time course trace of membrane potential of D. melanogaster muscle bundles before and after exposure to solvent control (DMSO). (B) Representative time course trace of membrane potential of D. melanogaster muscle bundles before and after exposure to increasing concentrations of VU041. (C) Total mV change in resting membrane potential over the 10-minute recording period in control (solvent only) treatments and VU041 treated flies. Bars represent average (n = 10) mV change while error bars represent SEM.