Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 25;8:1617. doi: 10.1038/s41598-018-20005-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Recordings of the electrically-evoked EPSPs at the neuromuscular junction in D. melanogaster larvae after exposure to VU041. (A) Representative time course of increasing VU041 concentrations applied to the body wall musculature while recording evoked EPSPs. The remaining transients after block of the EPSP at 30 μM are stimulus artifacts, which are also reflected by any negative excursions from baseline in all traces (artifact amplitudes were truncated from the recordings for clarity of display). The increase in membrane potential after the application of 30 μM is an artifact from the application of the drug and is not a direct response to VU041 since it was not observed in any other recording. (B) Representative time course of increasing VU937 concentrations applied to the body wall musculature while recording evoked EPSPs. (C) Representative evoked EPSP waveforms after exposure to 10 μM VU041 when compared to control.