Table 3.
Comparison of GT-B active sites
| Enzyme | PDB | Inverting/ retaining | Catalytic base | Pyrophosphate | Pyro phos. | Ribose | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LpxB | 5W8X | I | E15 | S17 | D98 | P198 | G199 | S200 | R201 | T277 | E281 |
| MurG | 1NLM | I | NA | T16 | H19 | G190 | G191 | S192 | NA | T266 | E269 |
| Δ24PmST1 | 2IHZ | I | NA | S36 | D141 | NA | NA | NA | NA | NA | E338 |
| MshA | 3C4V | R | NA | NA | NA | NA | NA | NA | NA | NA | E324 |
| NST | 2YK7 | I | NA | NA | D258 | NA | NA | S322 | NA | NA | E300 |
| PimA | 2GEJ | R | Y9 | NA | NA | NA | NA | NA | R196 | NA | E282 |
| WaaA | 2XCU | I | NA | NA | E31 | NA | NA | NA | R212 | NA | E276 |
Residues shown are those found to be analogous to LpxB active site residues by comparison of listed crystal structures
NA, not applicable, indicates that an analogous residue could not be unambiguously assigned