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. 2018 Jan 25;8:1601. doi: 10.1038/s41598-018-20021-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution and accumulation of ET in mouse liver, whole blood, spleen, kidney, lung, heart, small intestine (jejunum/ileum), eye, large intestine, and brain (cortex). (a) Basal ET concentration in mice administered with single dose of saline (1-day control), n = 7. (b) Maximum ET accumulation in mice fed with 70 mg/kg/day ET for 28 days, n = 7. (c) Rate of ET accumulation was determined by calculating the fold change between maximum and basal ET concentrations. All values are expressed with standard error.