Fig. 8.

Model for the role of Ino80 and regional coronary vascularization during heart wall growth. Two major progenitors of coronary vessels exist, the sinus venosus (SV, red) and endocardial cells (endo, green). These progenitors grow into the ventricle walls from different sides of the heart and connect to form the coronary vascular bed, which is coincident with expansion of the compact myocardium. Deletion of Ino80 from each progenitor pool separately, or together using cell type specific Cre lines, results in either medium or severe heart wall thinning/ventricular non-compaction, respectively. Ino80 occupies E2F target gene promoters and suppresses their expression, limiting cells in S-phase and allowing proper angiogenesis. These models highlight that increasing the amount of vasculature through access to multiple progenitor sources accelerate expansion of the heart wall during development. Major depletion of coronary vasculature results in severe LVNC-like phenotypes