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. 2018 Jan 25;8:1595. doi: 10.1038/s41598-018-20043-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of the two basic types of epithelial cells in terms of p53-dependency. Specific metabolic states and/or expression of oncogenes may cause the transition of epithelial cells from being p53-independent to p53-dependent, in which p53 maintains epithelial gene expression through the actions of H3K27me3-specific histone lysine demethylase(s) (KDM) and histone acetyltransferase(s) (HAT)⁴⁰.