Figure 3.

A: Metabolically normal, lean adipose tissue produces anti-inflammatory cytokines and is associated with CD4⁺ T cells and M2 macrophages. B: As obesity increases, adipocytes undergo hypertrophy, begin to produce proinflammatory cytokines, and are associated with CD8⁺ T cells and M1 macrophages. C: Finally, as metabolic dysfunction worsens, adipose tissue produces only proinflammatory cytokines, and crown-like structures of necrotic adipocytes surrounded by M1 macrophages appear. CCL2, chemokine (C-C motif) ligand 2; IFN-γ, interferon-γ; IL, interleukin; TNBC, triple-negative breast cancer.