A: Age-adjusted incidence rates of colorectal cancer (CRC) in African Americans (purple) and whites (green; explicitly non-Hispanic whites) from 1992 to 2014, all ages, both sexes [data from Surveillance, Epidemiology, and End Results (SEER) 13, Incidence–SEER 13 Regs Research Data, November 2016 Sub (1992 to 2014) <Katrina/Rita Population Adjustment>; https://seer.cancer.gov/data/seerstat/nov2016, accessed April 14, 2017]. Annual percentage change is depicted as text above data, where negative values indicate a decreasing trend and positive values indicate an increasing trend. Asterisks denote a rising or falling trend, where the entire 95% CI is above or below 0, respectively. No asterisk indicates a stable trend. B: Age-adjusted US mortality rates of CRC in African Americans (purple) and whites (green; explicitly non-Hispanic whites) from 1992 to 2014, all ages, both sexes (data from SEER 13). Annual percentage change is depicted as text above data, where negative values indicate a decreasing trend.