Table 1.
Gene region∗ | Chr | SNP ID | Position, bp | Allele | F(A) | OR | P value | Ref | Notes |
---|---|---|---|---|---|---|---|---|---|
LINC01655 | 1q41 | 12759486 | 222,066,536 | T | 0.58 | 0.86 | 1.5 × 10−4 | 19 | Fine-mapping SNP |
C5orf66 | 5q31.1 | rs647161 | 134499052 | A | 0.55 | 1.14 | 0.002 | 19 | Index SNP |
SLC22A3† | 6q26-27 | rs7758229 | 160,840,252 | T | 0.11 | 1.08 | 0.056 | 19 | Index SNP |
EIF3H | 8q23.3 | rs16892766 | 117,630,683 | C | 0.13 | 1.17 | 0.0058 | 19 | Index SNP |
EIF3H | 8q23.3 | rs16892766 | 117,630,683 | C | 0.13 | 1.15 | 0.19 | 20 | Index SNP |
MYC | 824.21 | rs6983267 | 128,413,305 | T | 0.13 | 0.87 | 0.029 | 19 | Index SNP |
MYC | 824.21 | rs6983267 | 128,413,305 | T | 0.12 | 0.87 | 0.21 | 20 | Index SNP |
MYC | 824.21 | rs7014346 | 128,424,792 | G | 0.39 | 1.05 | 0.27 | 19 | Index SNP |
MYC | 824.21 | rs7014346 | 128,424,792 | G | 0.39 | 1.15 | 0.06 | 20 | Index SNP |
POLD3 | 11q13.4 | rs3824999 | 74,345,550 | G | 0.20 | 1.15 | 0.009 | 19 | Index SNP |
GREM1 | 15q13.3 | rs16969681 | 32,993,111 | T | 0.13 | 1.16 | 0.01 | 19 | Index SNP |
GREM1 | 15q13.3 | rs10318 | 33,025,979 | T | 0.03 | 1.45 | 0.04 | 20 | Index SNP |
GREM1 | 15q13.3 | rs11632715 | 33,004,247 | A | 0.38 | 1.04 | 0.34 | 19 | Index SNP |
GREM1 | 15q13.3 | rs11632715 | 33,004,247 | A | 0.29 | 2.36‡ | 0.004 | 20 | Index SNP |
GREM1 | 15q13.3 | rs17816285 | 33,039,298 | G | 0.29 | 3.13‡ | 2 × 10−4 | 21 | Novel SNP association |
CDH1 | 16q22.1 | rs9929218 | 68,820,946 | A | 0.29 | 0.93 | 0.12 | 19 | Index SNP |
CDH1 | 16q22.1 | rs1862748 | 68,832,943 | T | 0.20 | 0.82 | 0.023 | 20 | Index SNP |
RHPN2 | 19q13.1 | rs7252505 | 33,575,064 | A | 0.62 | 0.85 | 1.8 × 10−4 | 19 | Fine-mapping SNP |
RHPN2 | 19q13.1 | rs113984415 | 33,555,034 | A | 0.19 | 0.13 | 8 × 10−5 | 21 | Novel SNP association |
CASC20 | 20p12.3 | rs961253 | 6,404,281 | A | 0.36 | 1.08 | 0.054 | 19 | Index SNP |
CASC20 | 20p12.3 | rs961253 | 6,404,281 | A | 0.37 | 0.93 | 0.30 | 20 | Index SNP |
The studies by Wang et al19 and Kupfer et al20 included African American subjects comparing 1894 cases with 4703 controls and 795 cases with 985 controls, respectively. Wang et al19 tested 21 risk-associated regions, and Kupfer et al20 tested 10 risk-associated regions. The two studies share a small subset of North Carolina subjects. Two novel associations were reported for GREM1 and RHPN2 in the study by Kupfer et al.21 Fine-mapping SNP is an SNP correlated with the index SNP that showed a stronger association P value. Unless otherwise stated, a log-additive model was used to estimate effect size and P value.
Allele, allele used as reference; Chr, chromosome; F(A), frequency of the reference allele; ID, identification; OR, odds ratio (not adjusted for local ancestry); P value, P value of association; Ref, article from which data were reproduced; SNP, single-nucleotide polymorphism.
Assignment of a gene to the association is based on proximity to the nearest risk-associated SNP.
The association shown was observed for left-sided colorectal cancer only. No association was observed for all colorectal cancer.
Recessive model.