Table 1.

Associations Identified in Two Replication Studies that Tested for Association at Known Susceptibility Regions

Gene region∗	Chr	SNP ID	Position, bp	Allele	F(A)	OR	P value	Ref	Notes
LINC01655	1q41	12759486	222,066,536	T	0.58	0.86	1.5 × 10−4	19	Fine-mapping SNP
C5orf66	5q31.1	rs647161	134499052	A	0.55	1.14	0.002	19	Index SNP
SLC22A3†	6q26-27	rs7758229	160,840,252	T	0.11	1.08	0.056	19	Index SNP
EIF3H	8q23.3	rs16892766	117,630,683	C	0.13	1.17	0.0058	19	Index SNP
EIF3H	8q23.3	rs16892766	117,630,683	C	0.13	1.15	0.19	20	Index SNP
MYC	824.21	rs6983267	128,413,305	T	0.13	0.87	0.029	19	Index SNP
MYC	824.21	rs6983267	128,413,305	T	0.12	0.87	0.21	20	Index SNP
MYC	824.21	rs7014346	128,424,792	G	0.39	1.05	0.27	19	Index SNP
MYC	824.21	rs7014346	128,424,792	G	0.39	1.15	0.06	20	Index SNP
POLD3	11q13.4	rs3824999	74,345,550	G	0.20	1.15	0.009	19	Index SNP
GREM1	15q13.3	rs16969681	32,993,111	T	0.13	1.16	0.01	19	Index SNP
GREM1	15q13.3	rs10318	33,025,979	T	0.03	1.45	0.04	20	Index SNP
GREM1	15q13.3	rs11632715	33,004,247	A	0.38	1.04	0.34	19	Index SNP
GREM1	15q13.3	rs11632715	33,004,247	A	0.29	2.36‡	0.004	20	Index SNP
GREM1	15q13.3	rs17816285	33,039,298	G	0.29	3.13‡	2 × 10−4	21	Novel SNP association
CDH1	16q22.1	rs9929218	68,820,946	A	0.29	0.93	0.12	19	Index SNP
CDH1	16q22.1	rs1862748	68,832,943	T	0.20	0.82	0.023	20	Index SNP
RHPN2	19q13.1	rs7252505	33,575,064	A	0.62	0.85	1.8 × 10−4	19	Fine-mapping SNP
RHPN2	19q13.1	rs113984415	33,555,034	A	0.19	0.13	8 × 10−5	21	Novel SNP association
CASC20	20p12.3	rs961253	6,404,281	A	0.36	1.08	0.054	19	Index SNP
CASC20	20p12.3	rs961253	6,404,281	A	0.37	0.93	0.30	20	Index SNP

The studies by Wang et al¹⁹ and Kupfer et al²⁰ included African American subjects comparing 1894 cases with 4703 controls and 795 cases with 985 controls, respectively. Wang et al¹⁹ tested 21 risk-associated regions, and Kupfer et al²⁰ tested 10 risk-associated regions. The two studies share a small subset of North Carolina subjects. Two novel associations were reported for GREM1 and RHPN2 in the study by Kupfer et al.²¹ Fine-mapping SNP is an SNP correlated with the index SNP that showed a stronger association P value. Unless otherwise stated, a log-additive model was used to estimate effect size and P value.

Allele, allele used as reference; Chr, chromosome; F(A), frequency of the reference allele; ID, identification; OR, odds ratio (not adjusted for local ancestry); P value, P value of association; Ref, article from which data were reproduced; SNP, single-nucleotide polymorphism.

^∗Assignment of a gene to the association is based on proximity to the nearest risk-associated SNP.

^†The association shown was observed for left-sided colorectal cancer only. No association was observed for all colorectal cancer.

^‡Recessive model.