Table 5.
Adjusted Mean Difference between Procedure Types (with DIEP as Reference Category) on BREAST-Q and PROMIS
| PRO | Procedure | One year post-op | Two years post-op | ||
|---|---|---|---|---|---|
|
|
|
||||
| Adjusted mean difference1(95% CI) | P | Adjusted mean difference1(95% CI) | P | ||
| BREAST-Q: Satisfaction with breast | DIEP | -Ref- | -Ref- | ||
| PTRAM | 1.36 (−3.45, 6.17) | 0.577 | 2.67 (−2.53, 7.87) | 0.313 | |
| FTRAM | 0.04 (−4.56, 4.63) | 0.987 | 2.12 (−2.90, 7.14) | 0.406 | |
| SIEA | −1.82 (−6.37, 2.72) | 0.431 | 0.42 (−5.56, 6.40) | 0.889 | |
|
| |||||
| BREAST-Q: Psychosocial well-being | DIEP | -Ref- | -Ref- | ||
| PTRAM | 1.27 (−3.43, 5.97) | 0.595 | 0.62 (−3.95, 5.20) | 0.789 | |
| FTRAM | −1.14 (−5.33, 3.05) | 0.593 | −0.08 (−5.33, 5.18) | 0.977 | |
| SIEA | −0.67 (−5.66, 4.32) | 0.791 | 1.64 (−3.64, 6.91) | 0.541 | |
|
| |||||
| BREAST-Q: Physical well-being (chest and upper body) | DIEP | -Ref- | -Ref- | ||
| PTRAM | 1.52 (−1.94, 4.99) | 0.388 | −3.92 (−7.66, −0.18) | 0.040 | |
| FTRAM | −1.55 (−5.35, 2.24) | 0.417 | −2.22 (−5.89, 1.45) | 0.234 | |
| SIEA | 3.42 (−0.22, 7.05) | 0.065 | 0.76 (−3.44, 4.95) | 0.722 | |
|
| |||||
| BREAST-Q: Physical well-being (abdomen) | DIEP | -Ref- | -Ref- | ||
| PTRAM | −4.01 (−8.48, 0.45) | 0.078 | −7.22 (−12.30, −2.14) | 0.006 | |
| FTRAM | −4.16 (−8.33, 0.02) | 0.051 | −4.90 (−9.50, −0.31) | 0.037 | |
| SIEA | 4.72 (−0.07, 9.52) | 0.053 | 0.58 (−4.79, 5.95) | 0.832 | |
|
| |||||
| BREAST-Q: Sexual well-being | DIEP | -Ref- | -Ref- | ||
| PTRAM | 0.81 (−4.31, 5.93) | 0.755 | −2.61 (−8.97, 3.75) | 0.416 | |
| FTRAM | −2.33 (−7.10, 2.44) | 0.335 | 2.35 (−3.40, 8.10) | 0.420 | |
| SIEA | −2.66 (−8.63, 3.31) | 0.378 | 1.97 (−4.15, 8.09) | 0.526 | |
|
| |||||
| PROMIS: Physical function | DIEP | -Ref- | -Ref- | ||
| PTRAM | 0.00 (−2.09, 2.10) | 0.996 | 1.48 (−0.59, 3.55) | 0.159 | |
| FTRAM | −0.03 (−2.36, 2.30) | 0.980 | 0.42 (−1.52, 2.36) | 0.666 | |
| SIEA | 1.26 (−0.74, 3.26) | 0.212 | 1.20 (−1.09, 3.49) | 0.302 | |
|
| |||||
| PROMIS: Pain | DIEP | -Ref- | -Ref- | ||
| PTRAM | −0.07 (−2.10, 1.97) | 0.949 | 0.44 (−2.25, 3.13) | 0.745 | |
| FTRAM | 0.34 (−1.91, 2.60) | 0.761 | −0.50 (−2.57, 1.57) | 0.636 | |
| SIEA | −0.60 (−2.54, 1.34) | 0.544 | 0.11 (−2.34, 2.57) | 0.928 | |
1
Denotes the mean difference in PRO between the corresponding procedure type and DIEP (reference category); Based on separate mixed-effects regression model for each PRO outcome. Each model included as covariates baseline outcome, age, BMI, laterality, indication for mastectomy, timing of reconstruction, smoking status, diabetes, radiation and chemotherapy; Each model also included random intercepts for centers (hospitals) to account for between-center variability. The results were combined based on 10 multiply imputed data sets.