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Schematic illustration of OCT signal changes upon acid-triggered transformation of Au NCs. Small Au NPs (purple) are clustered via acid-cleavable linkers and further tethered with polyethylene glycol (PEG; blue) to prevent serum-mediated aggregation. Under acidic conditions (tumor microenvironment), the individual Au NPs will be dispersed, generating significantly reduced scattering intensity and increased Doppler variance frequency
