Table 2.

RANO criteria

Criterion	CR	PR	SD	PD
T1 gadolinium	None	≥ 50% ↑	< 50% ↑ but < 25 ↑	≥ 25% ↑
T2/FLAIR	Stable or ↓	Stable or ↑	Stable or ↑	↑
New lesion	None	None	None	Present
Corticosteroids	None	Stable or ↑	Stable or ↑	NAa
Clinical status	Stable or ↑	Stable or ↑	Stable or ↑	↑
Requirement for response	All	All	All	Any

CR complete response, PR partial response, SD stable disease, PD progression disease, ↑ increase, ↓ decrease, FLAIR fluid-attenuated inversion recovery, NA not applicable

^aIncrease in corticosteroids alone will not be taken into account in determining progression in the absence of persistent clinical deterioration