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. 2017 Nov 9;9(6):2081–2096. doi: 10.1016/j.stemcr.2017.10.009

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Contributions of Chromosomes to miRNA Generation in ESCs

(A) Chromosome pattern of miRNA expression in serum, 2i, and R2i cultures. The y axis indicates the number of miRNA-coding sequences within chromosomes which are transcribed as mature miRNAs. Each small RNA-sequencing datum was obtained from three independently grown cultures (independent experiments).

(B) Integrative Genomics Viewer (IGV) browser screenshot indicating miRNA read alignments in the 10^th intron of Sfmbt2 locus (chromosome 2). Small RNA-sequencing data were obtained for two ESC lines (RB18 and EB20) each time using pools of three independently grown cultures (independent experiments).

(C) IGV visualization of the read alignments of miRNAs embedded within the Dlk1-Dio3 locus (chromosome 12). Small RNA-sequencing data were obtained for two ESC lines (RB18 and EB20) each time using pools of three independently grown cultures (independent experiments).