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. 2018 Jan 19;8:2011. doi: 10.3389/fimmu.2017.02011

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Copyright © 2018 Tian, Zhou, Yang, Yu, Luo, Tian, Wang, Cui, Chen, Fu and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wt and lab-attenuated rabies virus infection in mice. Groups of C57BL/6 mice (n = 10) were intracerebally (i.c.) inoculated with 20 FFU DRV or B2c, and observed daily for 2 weeks. (A) The survival ratio was presented and analyzed by Log-rank (Mantel-Cox) test. (B) Groups of C57BL/6 mice (n = 5) were i.c. infected with 200 FFU DRV or 20 FFU B2c. At indicated time points p.i., N mRNA of DRV and B2c in the mouse brain was analyzed by qRT-PCR. (C) The change of blood–brain barrier permeability in the DRV-, B2c-, and mock-infected mouse brain was determined by measuring the Na-fluorescence uptake. (D) The inflammation in DRV-, B2c-, and mock-infected mouse brains was analyzed by immunohistochemistry using anti-CD45 antibody. The scale bars represent 20 µm. (E) The inflammation was quantified by counting CD45⁺ lymphocytes from at least three different randomly selected areas.