Figure 7.

BPIFB1 inhibits the EMT process through VTN and VIM in NPC cells. Expression of typical EMT markers, including E-cadherin, N-cadherin, BPIFB1, VIM, β-catenin, Slug, and Snail, according to western blot proteins from of 5-8F, HNE2, and HONE1 cells transfected with the (A) BPIFB1-Flag overexpression vector or (B) co-transfected with the BPIFB1-Flag and VTN-His vectors. GAPDH was used as an internal control. (C) Schematic model illustrating the role of BPIFB1 in regulating NPC migration and invasion by binding and interacting with VTN and VIM.