Table 3.
Top five significant networks from intolerant SNPs exclusively from the layer or broiler line
| Moleculesa | Total no of molecules | Score | Top diseases and functions |
|---|---|---|---|
| Layer line | |||
| BPI, DISC1, DYX1C1, IRG1, KNTC1, MAST2, MLKL, ODF2L, TELO2, TPO | 34 | 54 | cellular morphology, assembly, organization and maintenance |
| ACO1, FSH, ING1, LH, NEB, NPR2, PHKA2, RB1CC1, TNK2, Tropomyosin | 27 | 37 | organ morphology, organismal development and reproductive system development |
| AFF1, BARD1, CDC2, Cyclin A, Cyclin D, Cyclin E, EFHC1, ESR1, GNPAT, RB | 27 | 37 | developmental disorder, immunological disease and cancer |
| Alpha tubulin, Beta Tubulin, Dynein, EDIL3, ERK, FBN1, GPSM2, Growth Factor Receptor, INCENP, NPHP1 | 26 | 35 | cellular assembly, organization, function, maintenance and cycle |
| ADCY, Caveolin, FHL5, GLUD1, IDH2, INSR, Insulin, LEPR, Proinsulin, Trypsin | 24 | 31 | reproductive system development, cellular growth and proliferation and endocrine system disorders |
| Broiler line | |||
| AMY2A, Amylase, Apyrase, DMBT1, EDA2R, NGNL2, INF2, NKRF, NUAK2, OTULIN | 32 | 41 | lipid metabolism, nervous system development and post-translational modification |
| AMOTL2, ERK, FBF1, IQCE, MIPOL1, SCEL, SETD5, SH3RF2, SMPD1, TIPIN | 32 | 41 | carbohydrate and drug metabolism and small molecule biochemistry |
| AKAP, AKAP6, AKAP9, DISC1, LXN, MAPRE3, PCNXL4, PPM1E, RPS6KA1, SCT | 32 | 41 | cellular morphology, assembly, organization, function and maintenance |
| DCHS1, DHX30, EFCAB11, ESR, FTSJ3, HEATR1, MGA, MRPL3, NDC1, UTRN | 31 | 38 | metabolic disease, hereditary disorder and cell cycle |
| Aconitase, CRISP2, LAMA1, MEF2, MYBPH, MYH2, MYO9A, NFS1, OFD1, Tubulin | 30 | 37 | cancer, dermatological diseases, organismal injury and abnormalities |
aExample of ten molecules present in each network