Table 6.
Effects of scFOS/OF supplementation on microbiota composition and/or fermentative activity
| Animal model | Diet | FOS dose | Duration | Microbiota fermentative activity | Microbiota composition | References |
|---|---|---|---|---|---|---|
| Male Wistar rats | 11.8% E fat, 69.4% E CHO (starch or fructose) | 10% OF | 4 w | ↑ caecum weight ↑ caecal SCFA (pool) content: ↓ acetate, ↑ propionate and butyrate |
ND | [61] |
| C57BL/6J female mice, depleted or not in n-3 PUFA | 14.3% E fat, 58.9% E CHO | 0.2g OF/ d | 24 d | ↑ caecal tissue and content weight | Caecum (STD diet): ↑Bifidobacterium spp., Bacteroides-Prevotella ↓ Lactobacillus spp. Caecum (n-3 depleted diet): ↑Bifidobacterium spp., Lactobacillus spp. = Bacteroides-Prevotella |
[22] |
| Male C57BL/6J gnotobiotic mice | 34.9% E fat, 26.3% E CHO | 10% scFOS | 6 w | ↑ empty and full caecum weight | Faeces: ↑ Bifidobacteria, C. coccoides ↓ C. leptum, ratio Bacteroides-Prevotella: C. coccoides |
[46] |
| Male Sprague-Dawley rats, DIO | 9.8% E fat, 77.5% E CHO | 3% OF | 6 w | ND | Caecum: ↑ Total bacteria ↑ Lactobacillus, Bifidobacterium and Bacteroides/Prevotella, ↓ C. leptum, C. cluster XI, ↓ % Firmicutes, ratio Firmicutes: Bacteroidetes |
[17] |
| Male Sprague-Dawley rats, DIO | 9.8% E fat, 77.5% E CHO | 10% OF | 8 w | ↑ caecum weight | Caecum: ↑ Bacteroides spp., Lactobacillus spp., Bifidobacterium spp., B. animalis ↓ C. coccoides, C. leptum, Clostridium Cluster XI and I, Enterobacteriaceae ↓ Ratio Firmicutes: Bacteroidetes |
[14] |
| Male Wistar rats – PX - 407 | 9.8% E fat, 77.5% E CHO | 10% or 15% scFOS | 6 w | ND | Caecum: ↑ Bifidobacteria and Lactobacilli |
[56] |
| Male Sprague Dawley rats, DIO | g/100g: casein (20.0), sucrose (49.9), soybean oil (10.0), lard (10.0) | 10% OF | 7 w | ↑ empty caecum weight | Faeces: ↑ Total bacteria ↑ Bifidobacterium spp. ↓ C. leptum = Lactobacillus spp., C. coccoides, Bacteroides/Prevotella |
[24] |
| Male Wistar rats, Streptozotocin | 20.4% E fat, 59.9% E CHO | 10% scFOS | 2 – 6 w | ↑ caecum weight | Caecum: ↑ Bifidobacteria, Lactobacilli |
[19] |
| Ob/ob C57BL/6 mice | 60% E fat, 20% E CHO | 10% OF | 5 w | ↑ caecum and colon weight | Caecum (qPCR): = Total bacteria ↑ Bifidobacterium spp., E. rectale/ C. coccoides group ↓ Firmicutes and Roseburia spp. = Bacteroidetes, Lactobacillus spp., Bacteroides-Prevotella group |
[18] |
CHO carbohydrates, d days, DIO diet-induced obesity, E energy, FOS fructo-oligosaccharides, G glucose, I insulin, ND no data, OF oligofructose, scFOS short-chain fructooligosaccharides, w weeks