Table 2.

Phase separated proteins whose function affects the cell cycle

Protein name	Effect on cell cycle		Phase separation
Nucleolus
FIBL	Knockdown reduces cell growth [57]		[12]
NPM-1a	Role in tumorigenesis [58]		[12]
Stress granule
eIF4G2	Knockdown induces apoptosis and impairs proliferation [59]		[9]
FUSa	Knockdown impairs cell proliferation [60]		[6, 8, 9, 51]
EWSa	Knockdown induces apoptosis and impairs proliferation [61]		[2]
hnRNPA1	Knockdown induces cell cycle arrest [62]		[7, 9]
TDP-43	Overexpression induces cell cycle arrest [63]		[64]
TIA-1	Knockdown promotes cell proliferation [65]		[9]
Centrosome
PCM-1	Involved in cell cycle progression [66]		[67]
Purinosome
PPAT	Regulates growth rate via de novo purine biosynthesis [68]		[69]
Nuclear pore
Nup98a	Regulates expression cell cycle genes [70]		[71]
T-cell receptor
LAT	Regulates T-cell activation and proliferation [72]		[40]

^a Highlights protein found as oncogenic fusion proteins [46–49, 52]