. 2018 Jan 25;19:4. doi: 10.1186/s40360-018-0194-5

Table 3.

Estimated parameters from the final MBPK model to evaluate effect of food on fenofibrate absorption and results from bootstrap

Parameters	Estimates (% RSE)	IIV %CV (% RSE)	IOV %CV (% RSE)	Bootstrap median ± S.E.
k_g (hr⁻¹)	0.0412 (8.5%)	31.7% (22.1%)	–	0.042 ± 0.0033
k_m&a (hr^− 1)	0.198 (28.9%)	–	–	0.172 ± 0.057
k_el (hr^− 1)	0.27 (13. 6%)	86.3% (29.2%)	44.9% (43.5%)	0.28 ± 0.048
V_c/F (L)	12.9 (27.8%)	93% (28.9%)	50.9% (22.6%)	11.91 ± 2.55
V_stomach (L)	0.049^a/1^a	–	–	0.049^a/1^a
V_duodenum (L)	0.045^a	–	–	0.045^a
k_g’ (hr⁻¹)	0.00971 (58.9%)	–	–	0.011 ± 0.005
k_out (hr⁻¹)	0.00972 (38.3%)	–	–	0.011 ± 0.005
E _bile	0.0239 (22.2%)	–	–	0.027 ± 0.091
MTIME1 (hr)	0^a	–	–	0^a
MTIME2 (hr)	6.94 (12.4%)	–	–	6.92 ± 1.11
E _food	0.617 (40.4%)	–	–	0.64 ± 0.19
E _Vc1	−0.394 (40.1%)	–	–	− 0.38 ± 0.12
E _Vc2	−0.461 (37.7%)	–	–	− 0.43 ± 0.14
Residual variability
Proportional error (% RSE)	0.608 (6.4%)			0.599 ± 0.038

^aFixed parameter