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. 2018 Jan 25;20:10. doi: 10.1186/s13075-017-1500-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Neurobehavioral testing and choroid plexus infiltration. BI-BTK-1-treated mice have improved cognitive function as evidenced by significant improvement in the object placement test (a). A trend toward improvement in the object recognition test was present as well (b). Treatment had no effect on depression-like behavior (c) (BI-BTK-1, n = 12; control, n = 12). d MRL/lpr mice demonstrate marked choroid plexus infiltration with lymphocytes and macrophages, as seen here in a section of the fourth ventricle. Treatment with BI-BTK-1 ameliorates this infiltration (e). Representative images are taken at × 10 (b and d) and × 20 (c) and shown from mice in the treated and control groups, and blindly scored using the scale described in “Methods” (f). BI-BTK-1, n = 12; control, n = 8 (**p < 0.01)