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. 2018 Jan 25;20:10. doi: 10.1186/s13075-017-1500-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Characterization of the choroid plexus infiltrates. a Flow cytometric analysis of choroid plexus (CP) infiltrating immune cells in a small pilot study (BI-BTK-1, n = 2; control, n = 2) revealed infiltration of leukocytes, T cells, B cells, and macrophages. Immunofluorescent staining confirmed large populations of macrophages (green) accumulating in the choroid plexus of control mice (b), and increased IgG deposits (magenta) compared to BI-BTK-1-treated mice (c). Control mice also had increased numbers of T cells (red), B cells (green), and C3 complement deposition (gray). d Macrophages infiltrating the control-treated mice CPs had an activated phenotype (Mac-2+) compared to the BI-BTK-2-treated mice. Representative images are shown in all panels (BI-BTK-1, n = 7; control, n = 7)