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. Author manuscript; available in PMC: 2018 Jan 26.
Published in final edited form as: Chem Res Toxicol. 2016 Dec 6;29(12):2194–2205. doi: 10.1021/acs.chemrestox.6b00384

Figure 3.

Figure 3

LC-NSI-HRMS chromatograms resulting from the NNN-P450 2A6 incubations. For all sections, the top chromatogram is the accurate parent mass extracted from full scan for NNC. The middle and bottom chromatograms are two accurate product ion masses extracted from MS2 fragmentation for NNC. Sections are as follows: (A) NNC standard, and NNC-P450 2A6 incubations containing all relevant enzymes and cofactors with incubation times of (B) 1 min, (C) 5 min, and (D) 10 min. RT = retention time; MA = Mass Area.