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. Author manuscript; available in PMC: 2018 Jan 26.
Published in final edited form as: Stem Cells. 2016 Feb 19;34(3):601–613. doi: 10.1002/stem.2298

Figure 4.

Figure 4

Analysis of high-resolution isoelectric focusing coupled liquid chromatography tandem mass spectrometry proteomics data of mesenchymal stem cell (MSC) exosomes comparing peripheral arterial disease (PAD) to intermediate condition (IC). (A): ClueGO network analysis of 400 most abundant proteins in PAD exosomes shows enrichment for effector proteins (blue boxes). (B): Panther pathway analysis of PAD exosomes shows abundance of angiogenesis related pathway proteins: epidermal growth factor receptor, fibroblast growth factor, and platelet derived growth factor pathway associated proteins (red asterisk indicate angiogenesis associated pathways). Analysis of three different donors for each condition. For differential expression t tests with multiple testing correction with an false discovery rate of 1% was used. Circles are color coded according to their associated functionality. Number of circles and larger diameter of circles indicate greater over representation.