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Enzymes (TCN2, MTR, MTRR, and MTHFR) are important in B12 and folate metabolism. TCN2 transports vitamin B12 (cobalamin) to cells. MTR converts homocysteine into methionine and 5-methyltetrahydrofolate to tetrahydrofolate. MTRR is essential for regenerating functional MTR. MTHFR converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate. TCN2 – transcobalamin; MTR – methionine synthase; MTRR – methionine synthase reductase; MTHFR – methylene tetrahydrofolate reductase.
