Table 4.
Correlation between SNP genotypes and allele frequencies and severity of childhood ASD.
| SNPs | Genotype/Allele | Moderate-severe n (%) | Severe n (%) | OR | 95% CI | P value |
|---|---|---|---|---|---|---|
| rs1801198 | ||||||
| C/C | 25 (20.5) | 18 (22.8) | 1 | |||
| C/G | 71 (58.2) | 42 (53.2) | 0.82 | 0.40–1.68 | 0.5906 | |
| G/G | 26 (21.3) | 19 (24.0) | 1.02 | 0.44–2.37 | 0.9726 | |
| C | 121 (49.6) | 78 (49.4) | 1 | |||
| G | 123 (50.4) | 80 (50.6) | 1.01 | 0.68–1.51 | 0.9651 | |
| rs1801394 | ||||||
| A/A | 75 (61.5) | 46 (58.2) | 1 | |||
| A/G | 40 (32.8) | 30 (38.0) | 1.22 | 0.67–2.23 | 0.5104 | |
| G/G | 7 (5.7) | 3 (3.8) | 0.70 | 0.17–2.84 | 0.6162 | |
| A | 190 (77.9) | 122 (77.2) | 1 | |||
| G | 54 (22.1) | 36 (22.8) | 1.04 | 0.64–1.68 | 0.8777 | |
| rs1805087 | ||||||
| A/A | 100 (82.0) | 68 (86.1) | 1 | |||
| A/G | 22 (18.05) | 11 (13.9) | 0.74 | 0.34–1.62 | 0.4436 | |
| A | 147 (93.0) | 222 (91.0) | 1 | |||
| G | 11 (7.0) | 22 (9.0) | 0.76 | 0.36–1.60 | 0.4648 | |
| rs1801133 | ||||||
| A/A | 22 (18.0) | 10 (12.7) | 1 | |||
| A/G | 59 (48.4) | 42 (53.2) | 1.57 | 0.67–3.65 | 0.2986 | |
| G/G | 41 (33.6) | 27 (34.2) | 1.45 | 0.59–3.53 | 0.4151 | |
| A | 103 (42.2) | 62 (39.2) | 1 | |||
| G | 141 (57.8) | 96 (60.8) | 1.13 | 0.75–1.70 | 0.5541 | |