Table 3.
Permeability (Pe) results of the test compounds from the PAMPA-BBB assay with their predicted penetration in CNS. (Data expressed as mean ± SEM of three independent experiments. CNS- indicates low passive CNS permeation).
| Compound | Pe (10–6 cm s−1) | Prediction |
|---|---|---|
| 5 | 2.78 ± 0.14 | CNS- |
| 22 | 2.28 ± 0.11 | CNS- |
| 23 | 3.08 ± 0.16 | CNS- |
| 25 | 2.72 ± 0.19 | CNS- |
| 26 | 3.66 ± 0.67 | CNS- |
| 27 | 2.80 ± 0.58 | CNS- |
| 32 | 3.22 ± 0.63 | CNS- |
| 33 | 1.05 ± 0.22 | CNS- |
| 34 | 2.09 ± 0.82 | CNS- |
| 42 | 2.60 ± 0.18 | CNS- |
| 43 | 3.47 ± 0.66 | CNS- |
| 44 | 3.58 ± 0.73 | CNS- |
| 46 | 2.84 ± 0.28 | CNS- |
| 47 | 3.28 ± 0.38 | CNS- |