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. 2018 Jan 26;8:1679. doi: 10.1038/s41598-018-19828-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Gbp1 downregulation on mitochondrial function in macrophages. (a) Gbp1 protein levels in mitochondrial fraction of Raw 264 macrophages treated with 10 ng/ml IFNγ for 24 hours. Full-length blots are provided in Supplementary Fig. 7. (b,c) OCR in Scr and Gbp1 Kd macrophages treated with LPS (100 ng/ml) for 4 hours, n = 5. (d,e) mRNA expression levels of genes encoding electron transport chain components CYCS and COXIV, CTP1b, Acox1, and CS in Scr and Gbp1 Kd macrophages treated with 100 ng/ml LPS for 4 hours, n = 3. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus Scr cells. Back.Corr.: Background Correction.