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. 2018 Jan 26;8:1624. doi: 10.1038/s41598-018-19602-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RT^Q151M:DNA complex preparation and structure determination. (a) The 38-mer DNA aptamer used in this study. The nucleotides with 2′-O-methyl modification are marked with asterisks. Nucleotide substitutions are colored in blue, and the positions adjusted for the HIV-1 RT N-site are highlighted in yellow. The original nucleotides reported by Miller et al.²⁷ are also indicated in red. (b) Ribbon representation showing the overall structures of the RT^Q151M:DNA:ETV-TP ternary complex, and (c) the superimposition of the RT^Q151M:DNA binary and RT^Q151M:DNA:ETV-TP ternary complexes. The p66, p51, and DNA of the ternary complex are colored in blue, pink, and cyan, respectively. All models of the binary complex are colored in gray. The side-chains of Met151 and Met184 of the ternary complex are shown as stick models and colored in yellow. The side-chains of Met151 and Met184 of the binary complex are shown in magenta. The bound ETV-TP is also shown as a stick model. The structural difference at the finger domain including the β2-β3 region is indicated by a red arrow.