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. 2018 Jan 26;8:1624. doi: 10.1038/s41598-018-19602-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simulated annealing F_o − F_c omit map for the bound Mg²⁺:dGTP (a) and Mg²⁺:ETV-TP (b). The metal-coordinating residues (Asp110, Asp185, and Val111) and the template nucleotide base-pairing with dGTP/ETV-TP (dC0) are shown as stick models. The map is contoured at the 2.6σ level. The exocyclic methylene in ETV-TP is indicated by a red arrow.