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HBV RT-mimicking HIV-1 RT mutants created in this study.
| Mutants | Motif B | Motif A | β2-β3 | Viral Replication | |||||
|---|---|---|---|---|---|---|---|---|---|
| Q151M | F160L | G112S | D113A | Y115F | F116Y | I63V | L74V | ||
| RTQ151M | ° | ++ | |||||||
| RTQ151M/F160L | ° | ° | − | ||||||
| RTQ151M/G112S/D113A | ° | ° | ° | + | |||||
| RTQ151M/Y115F/F116Y | ° | ° | ° | ++ | |||||
| RTQ151M/I63V/L74V | ° | ° | ° | ++ | |||||
Viral replication represents the viral replicability obtained from the results of viral replication kinetics as shown in Supplementary Fig. S2.
