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. 2018 Jan 26;8:1637. doi: 10.1038/s41598-018-20022-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CRM intensity profiles (equatorial cross-section) of a multi-component microsphere (SA/SCS-PMCG) after preparation (a–c), and after explantation from the intraperitoneal space of C57bl/6 mice 2 weeks post-implantation (d–f). (a,d) Optical image (bar equals to 200 µm). Spatial distribution of individual polymeric components within the entire microcapsule (b,e) and in the outermost region only (c,f) obtained from Raman signal normalized to the maximum intensity.