Table 1.

Kinase profiling using selected TNKS inhibitors at 10 μM. Dose response was measured for selected kinase-inhibitor pairs and inhibition-% or an IC₅₀ is shown.

Compound	CDK9	Akt	p42	p38	GSK3β	CK2	TNKS2
	34%	1%	14%	3%	57%	12%	400 nM
	31%	2%	3%	3%	11%	1%	15 nM
	16%	48%	18%	20%	4%	2%	10 nM
	6.2 µM	14.7 µM	—	—	—	—	660 nM
	16.1 µM*	13.3 µM	—	—	—	—	16 nM
	3.4 µM	1.6 µM	51%	45%	41%	2%	1,050 nM
	28.3 µM*	13.8 µM	—	—	—	—	145 nM
	12%	7%	2%	3%	7%	1%	5 nM
	9%	1%	3%	3%	3%	1%	25 nM

TNKS2 IC₅₀ values are shown for comparison.

^*The compound does not completely inhibit the enzyme at concentrations used. IC₅₀ value extrapolated by the analysis software might be not accurately estimated.