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. 2018 Jan 26;8:1638. doi: 10.1038/s41598-018-20095-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of neurological deficit of MCAO rats undergoing GFR and RFR intervention. The neurologic deficit scores were evaluated at 24 h after reperfusion with GFR and RFR mode according to a modified Hunter’s method with a scale of 0–4. (A) Overall distribution of the neurological deficit scores in GFR and RFR group. (B) Distribution of the neurological deficit scores in GFR and RFR group according to time interval with respect to MCAO. Data were presented as a percentage of the number of sample in each score to the total numbers of corresponding samples. Wilcoxon rank-of-rank tests were used to analyze the significant differences between the GFR and RFR groups and there was a shift of the distribution of neurological deficit scores toward mild outcomes in GFR group at 30 or 60 min after MCAO, rather than at 15 min, compared with that in RFR group.