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. 2018 Jan 26;8:1621. doi: 10.1038/s41598-018-20004-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trichostatin A and Vorinostat significantly suppressed the expression levels of HDAC1, 7 and 8, as well as vimentin, while upregulating E-cadherin expression in PANC-1 and MiaPaCa-2, at mRNA and protein levels. Graph of the effect of SAHA or TSA on the mRNA expression of HDAC1, HDAC7, HDAC8, E-cadherin and vimentin in (A) PANC-1 and (B) MiaPaCa-2 cells, compared with the untreated control cells. GAPDH mRNA was used as the control. (C) Changes in HDAC1, HDAC7, HDAC8, E-cadherin, vimentin, slug and snail protein expression after SAHA or TSA treatment. Fold change in expression is indicated. β-actin was loading control. *p < 0.05, **p < 0.01, ***p < 0.001.