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. 2018 Jan 26;8:1621. doi: 10.1038/s41598-018-20004-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trichostatin A induces the accumulation of acetylated histones H3 and H4 in PDAC cells and enhances the epigenetic activity of Vorinostat. (A) RT-PCR data showing co-reduction in the mRNA expression of HDAC-1, HDAC-7, HDAC-8, DNMT3B and LSD1 after treatemnt with SAHA and/or TSA. GAPDH mRNA was used as internal control. (B) Changes in the protein expression of Ac-H3, Ac-H4, H3K4me2, and H3K9me2 after treatment with SAHA and/or TSA. Histone H3 was used as loading control. Fold changes is indicated.