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. 2018 Jan 26;8:1621. doi: 10.1038/s41598-018-20004-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The anti-CSCs activity of Gemcitabine is enhanced in the presence of Trichostatin A or Vorinostat. (A) Knockdown efficiency of siHDAC-1 and siHDAC-7 in PANC-1 and MiaPaCa-2 cells (B) Images of sphere formation in siHDAC-1 or siHDAC-7 -infected PANC-1 and MiaPaCa-2, compared with scramble infected control cells. (C) Images showing the effect of Gemcitabine treatment of PANC-1 and MiaPaCa-2 cell-generated tumor spheres in the presence or absence of SAHA or TSA.