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. 2018 Jan 26;8:1621. doi: 10.1038/s41598-018-20004-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pictorial Abstract. A schematic summary showing SAHA or TSA inhibits the HDACs 1, 7 and 8 expression/activity by enhancing the cellular accumulation of acetylated histones H3 and H4, as well as methylated lysine 4 tail of histone H3, which subsequently lead to a disbalance in EMT factors in favor of the benign epithelial phenotype, inhibition of cancer metastasis and/or invasion, loss of cancer stemness, increased sensitivity to chemotherapy and better prognosis.