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. 2018 Jan 26;8:1667. doi: 10.1038/s41598-018-20053-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Footprinting analyses. (A) Sequence and secondary structure of pre-miR-372; (B) Lead(II) acetate probing of pre-miR-372 in the presence of 0, 1, 5, 10 and 50 µM of compound PA-1 (lanes 4–8). (B) Human Recombinant Dicer probing of pre-miR-372 in the presence of 0, 0.5, 1 and 5 µM of compound PA-1 (lanes 4–7). (C) RNase S1 probing of pre-miR-372 in the presence of 0, 1, 5, 10 and 50 µM of compound PA-1 (lanes 4–8). In all gels, lane 1 represents intact RNA, lane 2 and lane 3 represent the alkaline hydrolysis ladder and T1 digestion ladder, respectively. Gels were cropped for clarity and complete gels are presented in Supporting Information Fig. S9.