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. 2018 Jan 26;8:1653. doi: 10.1038/s41598-018-19661-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CP-Tg mouse resistance to Rose Bengal/laser beam-induced thrombotic stroke and death. (a) Real-time monitoring of carotid artery blood flow before and after Rose Bengal/laser-induced thrombotic occlusion of carotid arteries in a wild-type (top) and a CP-Tg mouse (bottom). The percentage change in reperfusion was calculated at different time intervals and plotted over time. Red squares and black squares indicate changes in perfusion in WT and TG mice, respectively. Rose Bengal (50 mg/kg) was injected through the tail vein, and the time of injection was considered as zero minutes. Blood reperfusion was recorded for a period of 120 minutes. (b) Average curves from the two groups of mice obtained using the identical method described in panel A (n = 10, p < 0.01). The data shown are the mean ± SD. The data from the last time point were analyzed by the student’s t-test.