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. 2018 Jan 26;9:400. doi: 10.1038/s41467-017-02797-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Mate preference and lordosis behavior depend on nitric oxide signaling. a nNOS knockout (nNOS^−/−) female mice do not show a male-directed preference, whereas female control littermates displayed a preference for the male. Strikingly, a single peripheral injection with SNAP+BAY 41-2272, NO donor and soluble guanylate cyclase agonist induced a significant preference for the male in nNOS^−/− female mice. *P ≤ 0.05; **P ≤ 0.01; one-sample t test (H0: mean equals 0); n = 6 (nNOS^+/+) and 7 (nNOS^−/−). b Lordosis behavior is disrupted in nNOS knockout (nNOS^−/−) mice, but restored by a peripheral injection of the NO donor SNAP (together with BAY 41-2272); *P ≤ 0.05; **P ≤ 0.01; Tukey’s multiple comparison test; n = 7 per group. c By contrast, a peripheral injection of either kisspeptin or GnRH failed to restore lordosis behavior in nNOS^−/− mice; ANOVA; n = 7 per group. d A peripheral injection with SNAP+BAY 41-2272-induced lordosis behavior in Kiss^−/− mice; *P ≤ 0.05; paired t test; n = 10 per group. nNOS the neuronal form of nitric oxide synthase, Kp-10 kisspeptin, SNAP S-nitroso-N-acetylpenicillamine. Bars represent the mean ± SEM. For all experimental details, see Supplementary Table 1