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. 2018 Jan 26;9:404. doi: 10.1038/s41467-017-02817-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Types of responses to reward. a The responses of all dSPNs and iSPNs to reward are shown as z-normalized Δfiring rate. Neural responses around the time of reward onset (1 s before and 3 s after) were converted as the difference in firing rates (Δfiring rate) between rewarded and unrewarded trials in 100 ms time bins, and then normalized to unit variance based on the mean and SD. b The z-normalized Δfiring rates were classified into four groups using k-means clustering along the first three components of a principal components analysis. c Mean normalized responses of each type plotted separately for rewarded vs. unrewarded trials. Shading, SEM. d Fractions of total SPNs (optically tagged and untagged SPNs combined, n = 446), dSPNs (n = 77), and iSPNs (n = 75) in types 1–4. *p < 0.05 (χ²-test)