Table 2.
Pharmacokinetic parameters of tacrolimus estimated by the non-compartmental analysis after administration of TAC alone or in combination with MMF.
| Parameter | TAC (mean ± SD) | TAC + MMF (mean ± SD) | P value |
|---|---|---|---|
| Cmax (ng/mL) | 33.5 ± 10.6 | 35.0 ± 12.5 | 0.5825 |
| tmax (h) | 1 (1–2) | 2 (1–4) | — |
| AUC0–12 (ng·h/mL) | 139.3 ± 61.7 | 167.3 ± 54.9 | <0.05 |
| AUC0–24 (ng·h/mL) | 180.2 ± 85.0 | 221.8 ± 71.0 | <0.05 |
| AUC0–48 (ng·h/mL) | 235.1 ± 117.4 | 292.0 ± 91.5 | <0.05 |
| AUC0–72 (ng·h/mL) | 267.9 ± 137.2 | 333.0 ± 103.9 | <0.05 |
| AUC0-inf (ng·h/mL) | 322.4 ± 174.1 | 393.6 ± 121.7 | <0.05 |
| CL/F (L/h) | 20.1 ± 10.7 | 14.2 ± 5.8 | <0.05 |
TAC, tacrolimus; MMF, mycophenolate mofetil; SD, standard deviation; Cmax, maximum concentration; tmax, time of maximum concentration; AUC, area under the blood concentration-time curve from time 0 to infinity or pre-specified time points; CL/F, apparent clearance.
CL/F was calculated from dose and AUC0-inf; tmax is presented as median (min-max); P value was obtained by paired t-test or signed rank test.