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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 23;1072:320–327. doi: 10.1016/j.jchromb.2017.11.026

Table 5.

Pharmacokinetic parameters of HCQ and DCQ after 5 mg/kg intravenous administration of HCQ (Mean ± SD, n=5).

Parameters Estimates (mean ± SD)
HCQ DCQ
C0 1746.9 ± 329.0 –
Cmax (ng/ml) NA 36.1 ± 11.2
t1/2 (hr) 12.7 ± 1.1 13.7 ± 5.6
AUC0−∞(hr×ng/mL) 5577.8 ± 881.8 383.9 ± 83.2
AUC0−last (hr×ng/mL) 5490.6 ± 890.0 369.3 ± 74.3
Vd (L/kg) 17.0 ± 4.3 NA
Cl (L/hr/kg) 0.9 ± 0.2 NA

Abbreviation: C0: concentration at time 0 hr, Cmax: concentration at time tmax, AUC: area under the curve from 0 to ∞ hr, Vd: volume of distribution, Cl: clearance, t1/2: terminal half-life. NA: Not applicable.