Table 5.
Parameters | Estimates (mean ± SD)
|
|
---|---|---|
HCQ | DCQ | |
C0 | 1746.9 ± 329.0 | – |
Cmax (ng/ml) | NA | 36.1 ± 11.2 |
t1/2 (hr) | 12.7 ± 1.1 | 13.7 ± 5.6 |
AUC0−∞(hr×ng/mL) | 5577.8 ± 881.8 | 383.9 ± 83.2 |
AUC0−last (hr×ng/mL) | 5490.6 ± 890.0 | 369.3 ± 74.3 |
Vd (L/kg) | 17.0 ± 4.3 | NA |
Cl (L/hr/kg) | 0.9 ± 0.2 | NA |
Abbreviation: C0: concentration at time 0 hr, Cmax: concentration at time tmax, AUC: area under the curve from 0 to ∞ hr, Vd: volume of distribution, Cl: clearance, t1/2: terminal half-life. NA: Not applicable.