Table 6.
Blood and tissues concentration (ng/mL) and tissue to blood concentration ratio (Kp) of HCQ, DCQ, BDCQ and DHCQ after 5 mg/kg Intra venous administration of HCQ (mean ± SD, n=5).
| Analytes | Time (hr) | Blood Conc. (ng/mL) | Liver Conc. (ng/g) | Kidney Conc. (ng/g) | Spleen Conc. (ng/g) | Lungs Conc. (ng/g) | Heart Conc. (ng/g) |
|---|---|---|---|---|---|---|---|
| HCQ | 6 | 131.2 ±24.0 | 1,918.3±130.3 | 1,465.4±441.5 | 1,899.9±103.1 | 3,395.9±611.4 | 816.11±279.4 |
| 24 | 58.6±26.3 | 700.6±347.1 | 887.7±541.0 | 673.1±350.5 | 1,739.3±1214.6 | 461.18±288.4 | |
| 72 | 4.7±1.2 | 26.8±41.6 | 89.8 ±46.4 | 41.0±37.8 | 147.5±72.9 | 31.1±11.8 | |
|
| |||||||
| DCQ | 6 | 24.5±3.9 | 1,322.4±143.6 | 530.7 ±160.6 | 340.0±17.9 | 417.0±92.4 | 121.6±32.9 |
| 24 | 12.7±6.3 | 453.4±196.4 | 473.8 ±297.4 | 144.5±74.8 | 277.7±177.6 | 92.2±48.4 | |
| 72 | 1.3±1.3 | 53.1±26.7 | 78.7 ±33.7 | 24.5±18.5 | 50.4±10 | 15.9±2.7 | |
|
| |||||||
| BDCQ | 6 | 2.1±0.7 | 671.8±135.6 | 116.4±25.1 | 50.6±6.9 | 73.8±19.9 | 22.9±7.3 |
| 24 | 2.1±0.8 | 294.4±148.9 | 128.7±71.8 | 31.6±16.1 | 64.0±53.4 | 23.7±12.6 | |
| 72 | 1.4±0.7 | 173.3±103.9 | 69.9±28.2 | 19.1±14.3 | 31.7±9.6 | 15.7±3.3 | |
|
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| HDCQ | 6 | 10.1±2.4 | 1,957.5±315.2 | 254.7±149.6 | 298.7±19 | 212.4±37.7 | 66.3±20.4 |
| 24 | 10.3±3.1 | 1,021.2±560.5 | 302.5±186.1 | 163.6±86.7 | 178.3±120.5 | 58.6±28.8 | |
| 72 | 5.6±2.9 | 277.9±83.1 | 103.6±38.1 | 69.0±74.3 | 61.9±13.6 | 22.9±2.21 | |
|
Tissue to blood concentration ratio (Kp) Mean ± SD | |||||||
| Time (hr) | Liver (Kp) | Kidney (Kp) | Spleen (Kp) | Lungs (Kp) | Heart (Kp) | ||
|
| |||||||
| HCQ | 6 to 72 | NA | 10.8±4.6 | 15.2±4.0 | 11.6±2.9 | 29.0±2.9 | 6.9±0.9 |
| DCQ | 6 to 72 | NA | 43.2±9.6 | 39.4±18.9 | 14.6±3.6 | 25.6±11.0 | 8.1±3.6 |
| BDCQ | 6 to 72 | NA | 195.4±110.1 | 55.7±5.4 | 17.7±5.8 | 29.5±6.4 | 11.2±0.2 |
| HDCQ | 6 to 72 | NA | 114.3±73.1 | 24.4±5.4 | 19.3±9.1 | 16.5±5.0 | 5.5±1.2 |
Abbreviation: Kp: Tissue to blood concentration ratio, NA: Not applicable.