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Inactivation is significantly determined by the DIII and DIV VSDs.57 After channel activation, IFM associates with the DIV-VSD to control inactivation onset. After ∼100 ms, the IFM also associates with the DIII-VSD, supporting its activated conformation. Only after the IFM dissociates from the DIII and DIV VSDs. © Hsu et al. Adapted by permission of the CC BY 4.0 license. Permission to reuse must be obtained from the rightsholder.57.
