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. 2017 Sep 21;11(6):517–533. doi: 10.1080/19336950.2017.1369637

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© 2017 Taylor & Francis

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Figure 5. — Accessory subunits involved in modulating Na_v1.5 inactivation: β-subunit (green),^59-74^,⁸⁰^,⁸¹^,⁸³^,^84,^143-145, fibroblast growth homologous factors (FHFs) (purple),⁹⁶^,⁹⁷^,⁹⁹^,^121,¹²² and the CaM/Ca²⁺ complex (yellow).²⁴^,⁸⁹^,⁹¹^,^95-97,^146-150 Environmental factors including extracellular pH,¹⁰¹^,¹⁰²^,¹⁰⁴^,^105,¹¹⁰ and temperature¹⁰³^,^112-120^,¹²² may also modulate Na⁺ channel inactivation.