Table 2. Differentially targeted transcription factors, CVG vs OV comparison.
| Gene Symbol |
Group | p value | Adjusted p value |
Notes |
|---|---|---|---|---|
| ZNF121 | Down, Stage 13 | 1.63E-07 | 2.43E-04 | Transcription regulation |
| TRIM13 | Down, Stage 13 | 2.12E-06 | 1.41E-03 | Involved in turnover of membrane and secretory proteins from the endoplasmic reticulum; signal transducer activity |
| MED6 | Down, Stage 13 | 7.83E-06 | 3.63E-03 | Transcription cofactor |
| NR1D2 | Down, Stage 13 | 2.55E-05 | 8.95E-03 | Transcriptional repressor regulating genes involved in circadian rhythm, metabolic function, and inflammatory response |
| PELP1 | Down, Stage 13 | 5.66E-05 | 1.40E-02 | Interacts with growth factor signaling components EGFR |
| HOXC4 | Down, Stage 13 | 6.78E-05 | 1.56E-02 | Developmental gene related to anterior-posterior positioning |
| ZXDA | Down, Stage 13 | 7.08E-05 | 1.59E-02 | Promotes transcription of MHC class I and II genes |
| ZNF140 | Down, Stage 13 | 1.00E-04 | 2.05E-02 | Transcriptional repressor |
| CREBRF | Down, Stage 13 | 1.20E-04 | 2.39E-02 | Negative regulator of endoplasmic reticulum stress response by CREB3 regulation |
| ZNF675 | Down, Stage 13 | 1.41E-04 | 2.67E-02 | Transcriptional regulation; involved in osteoclast differentiation by modulating TRAF6 signaling |
| SHOX | Up, Stage 13 | 4.89E-05 | 7.87E-02 | Controls growth and development |
| CREBRF | Up, Stage 15 | 3.49E-09 | 8.42E-06 | Negative regulator of endoplasmic reticulum stress response by CREB3 regulation |
| RORA | Up, Stage 15 | 1.63E-07 | 1.43E-04 | Key regulator of differentiation, development, immunity, circadian rhythm; regulates SHH expression and calcium-mediated signal transduction |
| PURA | Up, Stage 15 | 2.91E-07 | 2.01E-04 | Transcription activator |
| ZNF148 | Up, Stage 15 | 5.50E-07 | 3.43E-04 | Transcriptional regulator; mutations associated with global developmental delay |
| NFAT5 | Up, Stage 15 | 7.85E-07 | 4.74E-04 | T-cell related transcription factor, immune response |
| CREBZF | Up, Stage 15 | 1.14E-06 | 5.32E-04 | Suppresses transcriptional activation by CREB3 |
| EPM2AIP1 | Up, Stage 15 | 2.37E-06 | 7.84E-04 | Binds laforin, function unknown; mutations associated with epilepsy |
| EPHA5 | Up, Stage 15 | 2.86E-06 | 8.37E-04 | Mediates nervous system development, role in axon guidance and synaptogenesis |
| POU3F4 | Up, Stage 15 | 2.82E-06 | 8.37E-04 | Neural transcription factor, plays a role in inner ear development |
| RFX3 | Up, Stage 15 | 3.40E-06 | 9.66E-04 | Transcriptional activator, involved in differentiation during embryogenesis |
down: transcription factors less targeted by miRNA; up: transcription factors more targeted by miRNA; stage: the Carnegie embryonic stage. GeneCards® (www.genecard.org) was used for Notes [45].